Recently, quality of life research studies among lung cancer patient populations are continuously increasing, providing important data about patients’ well-being alterations during their disease journey. The aim of this review was to explore and discuss studies related to factors affecting lung cancer patients’ quality of life. For data collection MEDLINE and CINAHL data-bases were searched using the key words quality of life, lung cancer, well-being, antineoplasmatic treatment and distress. The main identified factors affecting lung can- cer patients’ quality of life were related to the patient, the disease and its treatment. Among the demographic and clinical factors found to affect these patients’ quality of life were older age, female gender, significant body weight loss and poor performance status. This literature review indicated that lung cancer patients experience significant physical, psychological and social distress, reflecting on their total well being. However, available research is limited exploring mostly the impact of physical symptoms distress on patients’ well being, than the impact of psychological, emotional and social problems or spiritual sequences. Antineoplasmatic treatment seems to have a multidimensional impact on lung cancer patients’ quality of life, but available research findings are mainly related to interference of chemotherapy than radiotherapy and surgery. In conclusion, despite that increasing body of research, due to unclear and conflicting findings, there is still a great need to further study the factors affecting lung cancer patients’ quality of life.